Efficacy of Zosteric Acid Sodium Salt on the Yeast Biofilm Model Candida albicans
Microbial Ecology, ISSN: 0095-3628, Vol: 62, Issue: 3, Page: 584-598
2011
- 49Citations
- 70Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations49
- Citation Indexes49
- 49
- CrossRef35
- Captures70
- Readers70
- 70
Article Description
Candida albicans is the most notorious and the most widely studied yeast biofilm former. Design of experiments (DoE) showed that 10 mg/L zosteric acid sodium salt reduced C. albicans adhesion and the subsequent biofilm formation by at least 70%, on both hydrophilic and hydrophobic surfaces of 96-well plates. Indeed, biofilm imaging revealed the dramatic impact of zosteric acid sodium salt on biofilm thickness and morphology, due to the inability of the cells to form filamentous structures while remaining metabolically active. In the same way, 10 mg/L zosteric acid sodium salt inhibited C. albicans biofilm formation when added after the adhesion phase. Contrary to zosteric acid sodium salt, methyl zosterate did not affect yeast biofilm. In addition, zosteric acid sodium salt enhanced sensitivity to chlorhexidine, chlorine, hydrogen peroxide, and cis-2-decenoic acid, with a reduction of 0. 5 to 8 log units. Preliminary in vitro studies using suitable primary cell based models revealed that zosteric acid sodium salt did not compromise the cellular activity, adhesion, proliferation or morphology of either the murine fibroblast line L929 or the human osteosarcoma line MG-63. Thus the use of zosteric acid sodium salt could provide a suitable, innovative, preventive, and integrative approach to preventing yeast biofilm formation. © 2011 Springer Science+Business Media, LLC.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=80052911772&origin=inward; http://dx.doi.org/10.1007/s00248-011-9876-x; http://www.ncbi.nlm.nih.gov/pubmed/21614460; http://link.springer.com/10.1007/s00248-011-9876-x; https://dx.doi.org/10.1007/s00248-011-9876-x; https://link.springer.com/article/10.1007/s00248-011-9876-x; http://www.springerlink.com/index/10.1007/s00248-011-9876-x; http://www.springerlink.com/index/pdf/10.1007/s00248-011-9876-x
Springer Science and Business Media LLC
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