Effects of the coexistence of late-life depression and mild cognitive impairment on white matter microstructure.

Citation data:

Journal of the neurological sciences, ISSN: 1878-5883, Vol: 338, Issue: 1-2, Page: 46-56

Publication Year:
2014
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PMID:
24387897
DOI:
10.1016/j.jns.2013.12.016
PMCID:
PMC4428544
Author(s):
Li, Wenjun; Muftuler, L Tugan; Chen, Gang; Ward, B Douglas; Budde, Matthew D; Jones, Jennifer L; Franczak, Malgorzata B; Antuono, Piero G; Li, Shi-Jiang; Goveas, Joseph S
Publisher(s):
Elsevier BV
Tags:
Neuroscience; Medicine
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article description
Late-life depression (LLD) and amnestic mild cognitive impairment (aMCI) are associated with white matter (WM) disruptions of the fronto-limbic and interhemispheric tracts implicated in mood regulation and episodic memory functions. This work investigates the extent of these WM abnormalities in patients LLD and aMCI when these diseases occur alone and when they coexist.