Alterations in Cortical Sensorimotor Connectivity following Complete Cervical Spinal Cord Injury: A Prospective Resting-State fMRI Study.

Citation data:

PloS one, ISSN: 1932-6203, Vol: 11, Issue: 3, Page: e0150351

Publication Year:
2016
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PMID:
26954693
DOI:
10.1371/journal.pone.0150351; 10.1371/journal.pone.0150351.t003; 10.1371/journal.pone.0150351.t001; 10.1371/journal.pone.0150351.t002; 10.1371/journal.pone.0150351.g002; 10.1371/journal.pone.0150351.g001
PMCID:
PMC4783046; 4783046
Author(s):
Akinwunmi Oni-Orisan; Mayank Kaushal; Wenjun Li; Jack Leschke; B. Douglas Ward; Aditya Vedantam; Benjamin Kalinosky; Matthew D. Budde; Brian D. Schmit; Shi-Jiang Li; Vaishnavi Muqeet; Shekar N. Kurpad; Michael G Fehlings Show More Hide
Publisher(s):
Public Library of Science (PLoS); Figshare
Tags:
Biochemistry, Genetics and Molecular Biology; Agricultural and Biological Sciences; Cell Biology; Neuroscience; Physiology; Science Policy; 69999 Biological Sciences not elsewhere classified; review board approval; sensorimotor network; cord injury patients; right precentral ROIs; SCI patients; activation patterns; Functional Neuroimages software; Cortical Sensorimotor Connectivity; region; fMRI; connectivity; Complete Cervical Spinal Cord Injury
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Functional magnetic resonance imaging (fMRI) studies have demonstrated alterations during task-induced brain activation in spinal cord injury (SCI) patients. The interruption to structural integrity of the spinal cord and the resultant disrupted flow of bidirectional communication between the brain and the spinal cord might contribute to the observed dynamic reorganization (neural plasticity). However, the effect of SCI on brain resting-state connectivity patterns remains unclear. We undertook a prospective resting-state fMRI (rs-fMRI) study to explore changes to cortical activation patterns following SCI. With institutional review board approval, rs-fMRI data was obtained in eleven patients with complete cervical SCI (>2 years post injury) and nine age-matched controls. The data was processed using the Analysis of Functional Neuroimages software. Region of interest (ROI) based analysis was performed to study changes in the sensorimotor network using pre- and post-central gyri as seed regions. Two-sampled t-test was carried out to check for significant differences between the two groups. SCI patients showed decreased functional connectivity in motor and sensory cortical regions when compared to controls. The decrease was noted in ipsilateral, contralateral, and interhemispheric regions for left and right precentral ROIs. Additionally, the left postcentral ROI demonstrated increased connectivity with the thalamus bilaterally in SCI patients. Our results suggest that cortical activation patterns in the sensorimotor network undergo dynamic reorganization following SCI. The presence of these changes in chronic spinal cord injury patients is suggestive of the inherent neural plasticity within the central nervous system.