Rapid in vivo detection of rat spinal cord injury with double-diffusion-encoded magnetic resonance spectroscopy.
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Magnetic resonance in medicine, ISSN: 1522-2594, Vol: 77, Issue: 4, Page: 1639-1649
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- Medicine; diffusion tensor imaging; double-diffusion encoding; double-pulsed field gradient; spinal cord; Biomedical Engineering and Bioengineering
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Diffusion-weighted imaging is a common experimental tool for evaluating spinal cord injury (SCI), yet it suffers from complications that decrease its clinical effectiveness. The most commonly used technique, diffusion tensor imaging (DTI), is often confounded by effects of edema accompanying acute SCI, limiting its sensitivity to the important functional status marker of axonal integrity. The purpose of this study is to introduce a novel diffusion-acquisition method with the goal of overcoming these limitations.