PlumX Metrics
Embed PlumX Metrics

Reduced inhibitory effects of clonidine and neuropeptide Y onH-noradrenaline release from synaptosomes of the medulla oblongata of the spontaneously hypertensive rat

Journal of Neural Transmission, ISSN: 0300-9564, Vol: 76, Issue: 3, Page: 181-189
1989
  • 7
    Citations
  • 0
    Usage
  • 7
    Captures
  • 0
    Mentions
  • 0
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

Article Description

The release ofH-noradrenaline (H-NA) evoked by high-K (15 mM) was studied in synaptosomes isolated from the medulla oblongata of the normotensive Wistar-Kyoto and spontaneously hypertensive male rat (14 weeks old) using a superfusion apparatus. Based on concentration-response curves clonidine was shown to have a reduced ability to inhibitH-NA release in synaptosomes isolated from the spontaneously hypertensive rat (SHR) versus the normotensive rat. Furthermore, only a high concentration of NPY (100 nM) had the ability to enhance the inhibitory effects of clonidine onH-NA release in synaptosomes isolated from the medulla oblongata of the SH male rat, while 1 nM of NPY was effective in synaptosomes isolated from the medulla oblongata of the normotensive Wistar-Kyoto rat. These results may indicate a reduced presynaptic α2-adrenoceptor and NPY receptor function to inhibitH-NA release from NA and/or adrenaline (A) nerve terminals in the medulla oblongata of the adult 14 weeks old SHR. © 1989 Springer-Verlag.

Provide Feedback

Have ideas for a new metric? Would you like to see something else here?Let us know