Reduced inhibitory effects of clonidine and neuropeptide Y onH-noradrenaline release from synaptosomes of the medulla oblongata of the spontaneously hypertensive rat
Journal of Neural Transmission, ISSN: 0300-9564, Vol: 76, Issue: 3, Page: 181-189
1989
- 7Citations
- 7Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations7
- Citation Indexes7
- CrossRef6
- Captures7
- Readers7
Article Description
The release ofH-noradrenaline (H-NA) evoked by high-K (15 mM) was studied in synaptosomes isolated from the medulla oblongata of the normotensive Wistar-Kyoto and spontaneously hypertensive male rat (14 weeks old) using a superfusion apparatus. Based on concentration-response curves clonidine was shown to have a reduced ability to inhibitH-NA release in synaptosomes isolated from the spontaneously hypertensive rat (SHR) versus the normotensive rat. Furthermore, only a high concentration of NPY (100 nM) had the ability to enhance the inhibitory effects of clonidine onH-NA release in synaptosomes isolated from the medulla oblongata of the SH male rat, while 1 nM of NPY was effective in synaptosomes isolated from the medulla oblongata of the normotensive Wistar-Kyoto rat. These results may indicate a reduced presynaptic α2-adrenoceptor and NPY receptor function to inhibitH-NA release from NA and/or adrenaline (A) nerve terminals in the medulla oblongata of the adult 14 weeks old SHR. © 1989 Springer-Verlag.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0024510570&origin=inward; http://dx.doi.org/10.1007/bf01260503; http://www.ncbi.nlm.nih.gov/pubmed/2732724; http://link.springer.com/10.1007/BF01260503; http://www.springerlink.com/index/pdf/10.1007/BF01260503; http://www.springerlink.com/index/10.1007/BF01260503; https://dx.doi.org/10.1007/bf01260503; https://link.springer.com/article/10.1007/BF01260503
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