Oxygen activation during the interaction between MPTP metabolites and synthetic neuromelanin - an ESR-spin trapping, optical, and oxidase electrode study
Biochemical and Biophysical Research Communications, ISSN: 0006-291X, Vol: 154, Issue: 2, Page: 781-788
1988
- 12Citations
- 4Captures
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Article Description
Oxidase electrode measurements as well as optical and electron spin resonance spectroscopic data have shown that synthetic neuromelanin oxidizes the neurotoxin metabolite 1-methyl-4-phenyl-2,3-dihydropyridinium in a dose-dependent manner forming 1-methyl-4-phenylpyridinium and hydrogen peroxide. Hydroxyl radicals are formed in this reaction which is promoted by iron chelates. In contrast, neither 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine nor 1-methyl-4-phenylpyridinium reacts with synthetic neuromelanin in a similar fashion. The mechanism of selective toxicity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in pigmented neuronal cells is discussed in the light of these findings.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/0006291X88902082; http://dx.doi.org/10.1016/0006-291x(88)90208-2; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0023742708&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/2840906; http://linkinghub.elsevier.com/retrieve/pii/0006291X88902082; http://api.elsevier.com/content/article/PII:0006291X88902082?httpAccept=text/xml; http://api.elsevier.com/content/article/PII:0006291X88902082?httpAccept=text/plain; https://linkinghub.elsevier.com/retrieve/pii/0006291X88902082; http://dx.doi.org/10.1016/0006-291x%2888%2990208-2; https://dx.doi.org/10.1016/0006-291x%2888%2990208-2
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