Investigation of donor KIR content and matching in children undergoing hematopoietic cell transplantation for acute leukemia
Blood Advances, ISSN: 2473-9529, Vol: 4, Issue: 7, Page: 1350-1356
2020
- 17Citations
- 28Captures
- 1Mentions
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations17
- Citation Indexes17
- 17
- Captures28
- Readers28
- 28
- Mentions1
- News Mentions1
- News1
Most Recent News
KIR Alloreactivity, Genotype in Unrelated Donor Selection Not Significant to Pediatric AML, ALL Outcomes
Unrelated donor selection should not be based on KIR in any of the evaluated settings, study results suggest. The use of donor killer immunoglobulin-like receptor
Article Description
Multiple models of donor killer immunoglobulin receptor (KIR) alloreactivity or KIR genotype have been reported to be protective against leukemia relapse after allogeneic transplantation. However, few studies have addressed this topic in the pediatric population. Here, we assessed the outcomes of allogeneic transplantation in children with acute lymphoblastic leukemia (ALL; n = 372) or acute myeloid leukemia (AML; n = 344) who received unrelated donor (URD) transplantation and were reported to the Center for International Blood and Marrow Transplant Research (CIBMTR) from 2005 to 2016. As expected in this pediatric population, most patients underwent myeloablative conditioning while in remission and with bone marrow as a stem cell source. We tested KIR ligand mismatch, KIR gene content (centromeric [Cen] B), KIR2DS1 mismatching, and Cen B/telomeric A using Cox regression models and found that none were significantly associated with either relapse or disease-free survival when considering the entire cohort of patients (ALL and AML), AML, or ALL separately. Moreover, there was no significant association with outcomes in the in vivo T-cell–depleted (ie, serotherapy) cohort. This study, which is the largest analysis of donor KIR in the pediatric acute leukemia population, does not support the use of KIR in the selection of URDs for children undergoing T-replete transplantation.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S2473952920313963; http://dx.doi.org/10.1182/bloodadvances.2019001284; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85083796906&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/32267930; https://ashpublications.org/bloodadvances/article/4/7/1350/454288/Investigation-of-donor-KIR-content-and-matching-in; https://dx.doi.org/10.1182/bloodadvances.2019001284
American Society of Hematology
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