Stability of novel urinary biomarkers used for lupus nephritis
Frontiers in Pediatrics, ISSN: 2296-2360, Vol: 10, Page: 974049
2022
- 3Citations
- 6Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations3
- Citation Indexes3
- Captures6
- Readers6
Article Description
Background: The Renal Activity Index for Lupus (RAIL) is a composite score of six urinary biomarkers (neutrophil gelatinase–associated lipocalin (NGAL), monocyte chemoattractant protein-1 (MCP-1), kidney injury molecule-1 (KIM-1), ceruloplasmin, adiponectin, and hemopexin) used to monitor lupus nephritis activity in children. We tested stability of RAIL biomarkers prior to meaningful clinical use. Methods: Urine samples were tested by ELISA under shipping conditions, freeze/thaw, ambient and longer-term storage. Statistical analysis was performed via Deming Regression, Bland-Altman and Spearman Correlation Coefficient. Results: Biomarker concentration were comparable to freshly collected urine following storage at −80 °C for up to 3 months, and at 4 or 25 °C up to 48 h followed by −80 °C. Neither shipping on dry or wet ice exposure nor addition of two freeze-thaw cycles led to loss of signal, with excellent Spearman Correlation coefficients under all conditions. Conclusions: RAIL biomarkers are stable following short-term storage at clinically relevant conditions.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85135958013&origin=inward; http://dx.doi.org/10.3389/fped.2022.974049; http://www.ncbi.nlm.nih.gov/pubmed/35967565; https://www.frontiersin.org/articles/10.3389/fped.2022.974049/full; https://dx.doi.org/10.3389/fped.2022.974049; https://www.frontiersin.org/journals/pediatrics/articles/10.3389/fped.2022.974049/full
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