Transforming activity of dna extracted from bkv-transformed hamster cells after passages in culture
Oncology (Switzerland), ISSN: 1423-0232, Vol: 43, Issue: 6, Page: 368-371
1986
- 2Citations
- 1Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations2
- Citation Indexes2
- CrossRef2
- Captures1
- Readers1
Article Description
Primary fetal rat fibroblasts (FRF cells) were transfected with DNA extracted from BKV-trans-formed hamster kidney cells at low passage after transformation (HKBK1P cells) and at high passage after transformation (HKBKhp cells). Two transformed rat cell lines were obtained, FRF-DNA-HKBK1P cells and FRF-DNA-HKBKhp cells, transformed by DNA extracted from HKBK1P cells and HKBKhp cells, respectively. They were characterized by a number of biological properties and by tumorigenicity and metastatic ability in newborn hamsters. The two transformed FRF cell lines exhibited exactly inverted properties in comparison with HKBK cells, in particular FRF-DNA-HKBK1P cells showed a low level of nuclear Τ antigen and a diffuse appearance of TSTA at the cell surface, whereas FRF-DNA-HKBKhp cells demonstrated a high level of Τ antigen and the capping of TSTA in the cell membrane. The tumorigenicity and the metastatic ability were greater with FRF-DNA-HKBK,,, cells, while FRF-DNA-HKBKhp cells appeared to be less tumorigenic and metastatic in newborn hamsters. © 1986 S. Karger AG, Basel.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0023035570&origin=inward; http://dx.doi.org/10.1159/000226404; http://www.ncbi.nlm.nih.gov/pubmed/3808570; https://karger.com/OCL/article/doi/10.1159/000226404; http://www.karger.com/?doi=10.1159/000226404; http://www.karger.com/Article/Abstract/226404
S. Karger AG
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