Selective C3 deficiency due to C3 nephritic factor in an apparently healthy girl
La Ricerca in Clinica e in Laboratorio, ISSN: 0390-5748, Vol: 15, Issue: 4, Page: 323-329
1985
- 11Citations
- 8Captures
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Metrics Details
- Citations11
- Citation Indexes11
- 11
- CrossRef7
- Captures8
- Readers8
Article Description
Routine laboratory investigations performed on the serum of an 8-year-old girl examined because of a moderate degree of iron-deficiency anemia showed a markedly reduced C3 level. More detailed complement studies revealed a selective C3 deficiency, as indicated by the almost undetectable C3 concentration tested by both hemolytic and immunochemical assays and by the normal or slightly reduced levels of all the other complement components. The hemolytic activity of the serum was restored by the addition of partially purified C3 component. The isolated C3 deficiency could be attributed to the presence of a C3-cleaving activity in the serum of the propositus. This activity was identified as C3 nephritic factor (C3NeF) since it was heat-stable, was absorbed by Cowan I strain of Staphylococcus aureus and was eluted in the IgG fraction after DEAE-chromatography of the serum. The levels of H and I factors of the alternative pathway in the serum of the propositus and of C3 in the serum samples of her parents and two siblings were found to be within the normal range. The previous clinical history of the girl and the follow-up for a period of approximately 5 years showed that she was apparently healthy and did not reveal clinical and/or laboratory evidence of glomerulonephritis, lipodystrophy or repeated bacterial infections usually associated with the presence of C3NeF in the serum. © 1985 Springer-Verlag.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0022141438&origin=inward; http://dx.doi.org/10.1007/bf03029146; http://www.ncbi.nlm.nih.gov/pubmed/3834579; https://link.springer.com/10.1007/BF03029146; https://dx.doi.org/10.1007/bf03029146; https://link.springer.com/article/10.1007/BF03029146
Springer Science and Business Media LLC
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