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Experimental epilepsy induced by cobalt powder in lower brain-stem and thalamic structures

Electroencephalography and Clinical Neurophysiology, ISSN: 0013-4694, Vol: 22, Issue: 6, Page: 525-536
1967
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Article Description

In chronic unrestrained unanaesthetized cats metallic cobalt powder in the lower brain-stem induced, as early as 24h after introduction, marked EEG changes characterized by hypersynchronous potentials, high voltage spikes, spike and wave complexes, generally associated with myoclonic jerks involving facial, cervical and forelimb flexor muscles. These changes generally faded away within 5–6 days. Generalized attacks of myoclonic type were also observed. Sensory stimulation had a driving effect on the electroclinical manifestations. Hypersynchronous potentials were driven by intermittent photic stimulation. The convulsive threshold to Metrazol injection was also definitely lowered.

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