Effects of a snake α neurotoxin on the development of innervated skeletal muscles in chick embryo
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 0027-8424, Vol: 70, Issue: 6, Page: 1708-1712
1973
- 79Citations
- 7Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations79
- Citation Indexes79
- 79
- CrossRef53
- Captures7
- Readers7
Article Description
The evolution of the cholinergic (nicotinic) receptor in chick muscles was monitored during embryonic development with a tritiated α neurotoxin from Naja nigricollis and compared with the appearance of acetylcholinesterase. The specific activity of these 2 proteins reached a maximum around the 12th day of incubation. By contrast, choline acetyltransferase reached an early maximum of specific activity around the 7th day of development, and later increased continuously until hatching. Injection of α toxin in the yolk sac at early stages of development caused an atrophy of skeletal and extrinsic ocular muscles and of their innervation. In 16 day embryos treated by the α toxin, the endplates revealed by the Koelle reaction were almost completely absent. The total content and specific activities of acetylcholinesterase and choline acetyltransferase in atrophic muscles were markedly reduced.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0015880661&origin=inward; http://dx.doi.org/10.1073/pnas.70.6.1708; http://www.ncbi.nlm.nih.gov/pubmed/4515929; https://pnas.org/doi/full/10.1073/pnas.70.6.1708; https://dx.doi.org/10.1073/pnas.70.6.1708; https://www.pnas.org/content/70/6/1708
Proceedings of the National Academy of Sciences
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