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Protective effect of ranitidine on acute experimental pancreatitis in the rat

Farmaco, Edizione Scientifica, ISSN: 0430-0920, Vol: 38, Issue: 2, Page: 135-142
1983
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Article Description

Acute experimental pancreatitis was induced in rats, with a polyethylene splint placed into the duodenum, by the closed duodenal loop technique. Ranitidine (20 mg . kg-1) or saline were administered intraperitoneally every 8 hrs, beginning 15 min prior to surgery. The degree of pancreatitis and the amylase to creatinine clearance ratio (ACCR) were evaluated in all the animals after sacrifice. Ranitidine-treated animals showed significant by reduced pancreatic damage and ACCR values in comparison with non-treated rats. These data confirm the efficacy of ranitidine as a preventive agent in the development of acute pancreatitis and suggest that controlled trials should be performed with this H2-antagonist in the human subyects with this disease.

Bibliographic Details

C. Scarpignato; G. Bertaccini; L. Sarli; M. Lupi; M. Gafà

Biochemistry, Genetics and Molecular Biology

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