Characterization of stereospecific binding of 3 H-(-)sulpiride, a selective antagonist at dopamine-D 2 receptors, in rat CNS
Pharmacological Research Communications, ISSN: 0031-6989, Vol: 15, Issue: 2, Page: 191-199
1983
- 8Citations
- 2Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations8
- Citation Indexes8
- CrossRef8
- Captures2
- Readers2
Article Description
Sulpiride endowed with dopamine (DA)-antagonist properties, does not antagonize neostriatal DA-sensitive adenylyl cyclase activity either in vitro or in vivo. Sulpiride however is able to displace radioactive ligands, which label DA-receptors, from their specific binding sites. On these bases sulpiride has been proposed as a selective antagonist at dopamine-D 2 receptors. We have characterized 3 H(-)sulpiride stereospecific binding in various rat brain areas. In particular, 3 H(-)sulpiride binding was found to be saturable, stereospecific and maximally enriched in the synaptic membrane fraction prepared from dopaminergic brain areas. Among a variety of compound tested only DA, DA-agonists and DA-antagonists were competitors for 3 H(-)sulpiride specific binding sites. The results suggest that 3 H(-)sulpiride may be an useful tool for the characterization and localization of dopamine D 2 -receptors.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0031698983800617; http://dx.doi.org/10.1016/s0031-6989(83)80061-7; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0020691077&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/6844376; https://linkinghub.elsevier.com/retrieve/pii/S0031698983800617; http://linkinghub.elsevier.com/retrieve/pii/S0031698983800617; http://api.elsevier.com/content/article/PII:S0031698983800617?httpAccept=text/xml; http://api.elsevier.com/content/article/PII:S0031698983800617?httpAccept=text/plain; http://dx.doi.org/10.1016/s0031-6989%2883%2980061-7; https://dx.doi.org/10.1016/s0031-6989%2883%2980061-7
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