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Specific binding of dl‐cloprostenol and d‐cloprostenol to PG F receptors in bovine corpus luteum and myometrial cell membranes

Journal of Veterinary Pharmacology and Therapeutics, ISSN: 1365-2885, Vol: 17, Issue: 6, Page: 455-458
1994
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Article Description

Prostaglandin F receptors (PGF Rs) were measured in bovine corpus luteum and myometrial cell membranes using a radiometric method. The inhibition of labelled PGF binding exerted by d‐cloprostenol, dl‐cloprostenol, PGF and PGE (l0– M to 10 M) was evaluated in vitro. Results strongly suggest that cloprostenol binding to PGFRs is stereospecific. d‐Cloprostenol and PGF were equipotent, about 150 times more potent than d‐cloprostenol (P < 0.05) and approximately 280 times more potent than PGE, (P < 0.05) in inhibiting [3H]PGF binding to corpus luteum cell membranes. Such differences were less evident in myometrial cell membranes, where d‐cloprostenol and PGF were about 10 times more potent than d‐cloprostenol (P < 0.05) and approximately 95 times more potent than PGE (P < 0.05). Copyright © 1994, Wiley Blackwell. All rights reserved

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