Non-respiratory components of heart rate variability in heart transplant recipients: Evidence of autonomic reinnervation?
Clinical Science, ISSN: 0143-5221, Vol: 86, Issue: 5, Page: 537-545
1994
- 45Citations
- 13Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations45
- Citation Indexes45
- 45
- CrossRef29
- Captures13
- Readers13
- 13
Article Description
1. Although the high-frequency fluctuations in R-R interval (respiratory sinus arrhythmia) observed in heart transplant recipients are not a reliable marker of reinnervation because of a previously shown direct mechanical effect of breathing, the presence of a non-respiration-related low-frequency oscillation reflects rhythms generated outside the heart, and thus could be neurally mediated. 2. To evaluate the presence of reinnervation, the spontaneous variability in R-R interval was investigated, supine and after passive tilting, in 23 heart transplant recipients (age 43 years, range 23- 64 years) and in 25 normotensive control subjects by autoregressive spectral analysis of low- and high-frequency spontaneous fluctuations in R-R interval and respiration. The response of R-R interval to amyl nitrite inhalation was also evaluated in five heart transplant recipients and eight control subjects. 3. Detectable low-frequency oscillations, unrelated to respiration, were present in 13/23 heart transplant recipients, particularly in those who were transplanted at least 20 months earlier (11/14). The natural logarithm of the power of low-frequency fluctuations was markedly lower than in control subjects (0.75±0.21 versus 5.62±0.20 ms, P<0.001). The low-frequency but not the high-frequency fluctuations correlated with time since transplantation (r=0.44, P<0.05). The subjects with low-frequency fluctuations showed a sudden decrease in R-R interval with amyl nitrite linearly related to the decrease in mean blood pressure (r ≥ 0.94). The slopes obtained in these heart transplant recipients were comparable (although of lower values) with those obtained in control subjects. The subjects with no low-frequency fluctuations showed no change in R-R interval despite a similar reduction in blood pressure. 4. Twenty months after transplantation signs of functional (reflex) reinnervation can be found in most heart transplant recipients.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0028298435&origin=inward; http://dx.doi.org/10.1042/cs0860537; http://www.ncbi.nlm.nih.gov/pubmed/7913430; https://portlandpress.com/clinsci/article/86/5/537/76177/Non-Respiratory-Components-of-Heart-Rate; https://dx.doi.org/10.1042/cs0860537; https://portlandpress.com/clinsci/article-abstract/86/5/537/76177/Non-Respiratory-Components-of-Heart-Rate?redirectedFrom=fulltext
Portland Press Ltd.
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