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An efficient Th2-type memory follows CD8 lymphocyte-driven and eosinophil-mediated rejection of a spontaneous mouse mammary adenocarcinoma engineered to release IL-4

Journal of Immunology, ISSN: 0022-1767, Vol: 153, Issue: 12, Page: 5659-5673
1994
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Article Description

A retroviral infection was used to introduce the cDNA coding for mouse IL- 4 into the parental cells of a spontaneous adenocarcinoma of BALB/c mice (TS/A-pc). Four clones releasing between 5 to 40 U of IL-4 (10 cells) in 48 h culture were selected. The secretion of IL-4 does not affect their in vitro growth, whereas their ability to form tumor in vivo inversely correlates with the amount of IL-4 secreted. Although morphologic observation suggested that the rejection of clone D5.40 cells (releasing 40 U of IL-4) depends on eosinophil cytolysis, lymphocyte depletion experiments showed that this required CD8 lymphocyte guidance. Mice that had rejected D5.40 cells were immune to a subsequent challenge with TS/A-pc. This memory rests on the interaction between noncytotoxic lymphocytes, eosinophils, and IgG1 and IgE anti-TS/A Abs. Comparison of these memory mechanisms with those elicited by IL-2 gene-transduced TS/A cells shows that the kind of cytokine released by the tumor cells determines the type of response. This Th2 memory seems to be more efficient in protecting against a subsequent challenge of TS/A-pc than the Th1-type memory elicited by IL-2 gene-transduced TS/A cells.

Bibliographic Details

Federica Pericle; Mirella Giovarelli; Federica Cavallo; Francesco Di Pierro; Francesco Novelli; Guido Forni; Mario P. Colombo; Giuliana Ferrari; Piero Musiani; Andrea Modesti

Medicine; Immunology and Microbiology

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