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Chemometric Methods Applied to an ICP-AES Study of Chemical Element Distributions in Autopsy Livers from Subjects Affected by Wilson and β- Thalassemia

Journal of Trace Elements in Medicine and Biology, ISSN: 0946-672X, Vol: 9, Issue: 4, Page: 215-221
1995
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The concentrations of seven elements (Ca, Cu, Fe, Mg, P, S and Zn) in three autopsy livers (from two β-thalassemic patients and one Wilson's disease patient) were determined by ICP-AES technique. At autopsy the three livers were subdivided into a large number of samples for a detailed study of the distribution of Fe and Cu, the accumulation of which characterizes the two diseases. In the same samples Ca, Mg, P, S and Zn concentrations were also determined in order to study significant variations or anomalous trends that could help identify these diseases. Our results generally show a good coincidence with literature data within the limits of sample variability. Based on Factor Analysis as well as Regression Analysis there is evidence of a high correlation between Fe and P contents in β-thalassemia. The latter finding led us to propose tentatively an accumulation of Fe as a complex with P-containing molecules.

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