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Survival and disease complications in thalassemia major

Annals of the New York Academy of Sciences, ISSN: 0077-8923, Vol: 850, Issue: 1, Page: 227-231
1998
  • 286
    Citations
  • 0
    Usage
  • 71
    Captures
  • 0
    Mentions
  • 0
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    286
    • Citation Indexes
      284
    • Clinical Citations
      1
      • PubMed Guidelines
        1
    • Policy Citations
      1
      • 1
  • Captures
    71

Conference Paper Description

We studied survival and disease complications in 1146 patients with thalassemia major, born from January 1, 1960 to December 31, 1987. At last follow-up, in March 1997, probability of survival to age 20 years was 89% and to age 25 years was 82% for patients born in the years 1970-1974. Patients who died had a serum ferritin level, measured the year before death, significantly higher than those who survived. Diabetes was present in 5.4% of the patients; heart failure in 6.4%, arrhythmias in 5.0%, thrombosis in 1.1%, hypothyroidism in 11.6%, HIV infection in 1.8%. Hypogonadism was diagnosed in 55% of 578 patients who had reached pubertal age: 83.5% of hypogonadic females and 78.6% of males were receiving substitutive hormonal therapy. In conclusion, the survival of patients with thalassemia major is good and improving, but the prevalence of severe complications is still high.

Bibliographic Details

Caterina Borgna-Pignatti; Simone Rugolotto; Piero De Stefano; Antonio Piga; Felicia Di Gregorio; Maria Rita Gamberini; Vincenzo Sabato; Caterina Melevendi; Maria Domenica Cappellini; Giuseppe Verlato

Wiley

Neuroscience; Biochemistry, Genetics and Molecular Biology; Arts and Humanities

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