Postsynaptic dopamine (D 2 )-mediated behavioural effects of high acute doses of artemisinin in rodents

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Brain Research Bulletin, ISSN: 0361-9230, Vol: 62, Issue: 3, Page: 255-260

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Amos, Samson; Chindo, B. A.; Abbah, J.; Vongtau, H. O.; Edmond, I.; Binda, L.; Akah, P. A.; Wambebe, C.; Gamaniel, K. S.
Elsevier BV; Elsevier Science
Neuroscience; Artemisinin; apomorphine; bromocriptine; behavior; dopamine (D2) receptor; locomotor activity; Behavior and Behavior Mechanisms; Medicine and Health Sciences; Organic Chemicals; Pharmacy and Pharmaceutical Sciences
article description
Artemisinin or qinghaosu is the active principle of quinghao ( Artemisia annua L.) developed from Chinese traditional medicine, which is now widely used around the world against falciparum malaria. Behavioural effects of high acute doses of artemisinin were studied on spontaneous motor activity (SMA), exploratory behavior, apomorphine-induced stereotype behavior and pentobarbital sleeping time in mice and rats in order to provide additional evidence on its safety profile on the central nervous system (CNS). Effects of the drug on bromocriptine-induced hyperactivity in short term reserpinised mice were also evaluated. Intraperitoneal (i.p.) injection of artemisinin at doses of 50 and 100 mg/kg, significantly ( P <0.05) reduced the SMA in mice, prolonged the pentobarbital sleeping time in rats, and attenuated the apomorphine-induced stereotypy in mice. Mice pretreated with reserpine, showed a significant decrease in locomotor activity compared to the saline-treated group. Bromocriptine, a D 2 receptor agonist, induced locomotor activity in mice pretreated with reserpine which was attenuated by artemisinin. The results suggest that artemisinin possesses sedative property, which may be mediated via postsynaptic dopamine (D 2 ) receptor in the CNS.