Treatment Patterns and Cost-Effectiveness of Chemotherapy Treatments among Advanced Gastric Cancer Patients

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Page: 1-94

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Haag, Austin Jade
thesis / dissertation description
This study examines the cost-effectiveness of the most-commonly used chemotherapy regimens for the treatment of gastric cancer. Although researchers have studied the cost-effectiveness of drugs used for the treatment of other types of cancer, no studies have examined the comparative cost-effectiveness of gastric cancer treatment regimens utilizing treatment patterns as the identifying methodology. Leucovorin + Fluorouracil (5-FU/LV), Carboplatin + Paclitaxel (CarboTaxol), and Fluorouracil (5-FU) were the most-commonly administered chemotherapy regimens during the period of 1999 to 2013. The use of Fluorouracil-containing regimens declined over time, while Carboplatin + Paclitaxel increased in use. Despite its increase in popularity, Carboplatin + Paclitaxel was estimated to increase all-cause mortality relative to Leucovorin + Fluorouracil. The receipt of Carboplatin + Paclitaxel was also associated with a higher total cost of treatment than Leucovorin + Fluorouracil. These negative results associated with the use of Carboplatin + Paclitaxel raise questions about the shift in treatment away from Fluorouracil-containing regimens in favor of Carboplatin + Paclitaxel, and the study discusses some possible reasoning behind the decision. ^