Stromal gene signatures in large-B-cell lymphomas.

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The New England journal of medicine, ISSN: 1533-4406, Vol: 359, Issue: 22, Page: 2313-23

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10.1056/nejmoa0802885; 10.3410/f.1148287.605435
Lenz, G; Wright, G; Dave, S S; Xiao, W; Powell, J; Zhao, H; Xu, W; Tan, B; Goldschmidt, N; Iqbal, J; Vose, J; Bast, M; Fu, K; Weisenburger, D D; Greiner, T C; Armitage, J O; Kyle, A; May, L; Gascoyne, R D; Connors, J M; Troen, G; Holte, H; Kvaloy, S; Dierickx, D; Verhoef, G; Delabie, J; Smeland, E B; Jares, P; Martinez, A; Lopez-Guillermo, A; Montserrat, E; Campo, E; Braziel, R M; Miller, T P; Rimsza, L M; Cook, J R; Pohlman, B; Sweetenham, J; Tubbs, R R; Fisher, R I; Hartmann, E; Rosenwald, A; Ott, G; Muller-Hermelink, H-K; Wrench, D; Lister, T A; Jaffe, E S; Wilson, W H; Chan, W C; Staudt, L M; Lymphoma/Leukemia Molecular Profiling Project Show More Hide
Faculty of 1000, Ltd.; New England Journal of Medicine (NEJM/MMS); Massachusetts Medical Society.
Medicine; Antibodies; Monoclonal; Murine-Derived; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Disease Progression; Doxorubicin; Extracellular Matrix; Gene Expression; Gene Expression Profiling; Gene Expression Regulation; Neoplastic; Genes; MHC Class II; Germinal Center; Humans; Immunologic Factors; Kaplan-Meier Estimate; Lymphoma; Large B-Cell; Diffuse; Middle Aged; Multivariate Analysis; Neovascularization; Pathologic; Prednisone; Prognosis; Rituximab; Stromal Cells; Vincristine; Medicine(all); Medical Microbiology; Pathology
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The addition of rituximab to combination chemotherapy with cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP), or R-CHOP, has significantly improved the survival of patients with diffuse large-B-cell lymphoma. Whether gene-expression signatures correlate with survival after treatment of diffuse large-B-cell lymphoma is unclear.