Exercise Improves Host Response to Influenza Viral Infection in Obese and Non-Obese Mice through Different Mechanisms.

Citation data:

PloS one, ISSN: 1932-6203, Vol: 10, Issue: 6, Page: e0129713

Publication Year:
2015
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Repository URL:
https://digitalcommons.unmc.edu/com_pulm_articles/2
PMID:
26110868
DOI:
10.1371/journal.pone.0129713; 10.1371/journal.pone.0129713.g007; 10.1371/journal.pone.0129713.g008; 10.1371/journal.pone.0129713.g009; 10.1371/journal.pone.0129713.g005; 10.1371/journal.pone.0129713.g004; 10.1371/journal.pone.0129713.g010; 10.1371/journal.pone.0129713.g002; 10.1371/journal.pone.0129713.g001; 10.1371/journal.pone.0129713.g003; 10.1371/journal.pone.0129713.g006
PMCID:
PMC4482026; 4482026
Author(s):
Kristi J. Warren; Molly M. Olson; Nicholas J. Thompson; Mackenzie L. Cahill; Todd A. Wyatt; Kyoungjin J. Yoon; Christina M. Loiacono; Marian L. Kohut; Paul G. Thomas
Publisher(s):
Public Library of Science (PLoS); Figshare
Tags:
Biochemistry, Genetics and Molecular Biology; Agricultural and Biological Sciences; Uncategorised; Weight loss; chemokine production; Different Mechanisms Obesity; iav; host response; ifn; control mice; influenza virus infection; disease severity; health benefits; exercise; cell infiltration; BAL cytokine; IgG 2c antibody; host defense; exercise treatment; Influenza Viral Infection; tnf; Allergy and Immunology; Critical Care; Respiratory System; Respiratory Tract Diseases
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article description
Obesity has been associated with greater severity of influenza virus infection and impaired host defense. Exercise may confer health benefits even when weight loss is not achieved, but it has not been determined if regular exercise improves immune defense against influenza A virus (IAV) in the obese condition. In this study, diet-induced obese mice and lean control mice exercised for eight weeks followed by influenza viral infection. Exercise reduced disease severity in both obese and non-obese mice, but the mechanisms differed. Exercise reversed the obesity-associated delay in bronchoalveolar-lavage (BAL) cell infiltration, restored BAL cytokine and chemokine production, and increased ciliary beat frequency and IFNα-related gene expression. In non-obese mice, exercise treatment reduced lung viral load, increased Type-I-IFN-related gene expression early during infection, but reduced BAL inflammatory cytokines and chemokines. In both obese and non-obese mice, exercise increased serum anti-influenza virus specific IgG2c antibody, increased CD8+ T cell percentage in BAL, and reduced TNFα by influenza viral NP-peptide-responding CD8+ T cells. Overall, the results suggest that exercise "restores" the immune response of obese mice to a phenotype similar to non-obese mice by improving the delay in immune activation. In contrast, in non-obese mice exercise treatment results in an early reduction in lung viral load and limited inflammatory response.