Protocol for a randomised, double-masked, sham-controlled phase 4 study on the efficacy, safety and tolerability of intravitreal aflibercept monotherapy compared with aflibercept with adjunctive photodynamic therapy in polypoidal choroidal vasculopathy: the ATLANTIC study.
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BMJ open, ISSN: 2044-6055, Vol: 7, Issue: 8, Page: e015785
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- Medicine; Fotoquimioterapia; Receptores de Factores de Crescimento do Endotélio Vascular; Acuidade Visual; Doenças da Coróide; Pólipos
The purpose of this study is to compare the efficacy and safety of intravitreal aflibercept (IVA) with sham photodynamic therapy (sPDT) versus IVA with verteporfin PDT (vPDT) in a Caucasian population with treatment-naive polypoidal choroidal vasculopathy (PCV), enrolling into a treat and extend (T&E) regimen.