Inflammation, organomegaly, and muscle wasting despite hyperphagia in a mouse model of burn cachexia.

Citation data:

Journal of cachexia, sarcopenia and muscle, ISSN: 2190-6009, Vol: 3, Issue: 3, Page: 199-211

Publication Year:
2012
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Citations 30
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Repository URL:
https://jdc.jefferson.edu/cbfp/36
PMID:
22476919
DOI:
10.1007/s13539-012-0062-x
PMCID:
PMC3424191; 3424191
Author(s):
Pedroso, Felipe E; Spalding, Paul B; Cheung, Michael C; Yang, Relin; Gutierrez, Juan C; Bonetto, Andrea; Zhan, Rui; Chan, Ho Lam; Namias, Nicholas; Koniaris, Leonidas G; Zimmers, Teresa A Show More Hide
Publisher(s):
Wiley-Blackwell
Tags:
Medicine; Inflammation; organomegaly; and muscle wasting despite hyperphagia in a mouse model of burn cachexia.; Medical Cell Biology
article description
Burn injury results in a chronic inflammatory, hypermetabolic, and hypercatabolic state persisting long after initial injury and wound healing. Burn survivors experience a profound and prolonged loss of lean body mass, fat mass, and bone mineral density, associated with significant morbidity and reduced quality of life. Understanding the mechanisms responsible is essential for developing therapies. A complete characterization of the pathophysiology of burn cachexia in a reproducible mouse model was lacking.