Effects of scleroderma antibodies and pooled human immunoglobulin on anal sphincter and colonic smooth muscle function.

Citation data:

Gastroenterology, ISSN: 1528-0012, Vol: 143, Issue: 5, Page: 1308-1318

Publication Year:
2012
Usage 197
Downloads 128
Abstract Views 67
Link-outs 2
Citations 17
Citation Indexes 17
Repository URL:
http://jdc.jefferson.edu/gastro_hepfp/14; https://works.bepress.com/vaibhav_mehendiratta/7
PMID:
22864255
DOI:
10.1053/j.gastro.2012.07.109
PMCID:
PMC3480560
Author(s):
Singh, Jagmohan; Cohen, Sidney; Mehendiratta, Vaibhav; Mendoza, Fabian A.; Jimenez, Sergio A.; DiMarino, Anthony J; Rattan, Satish
Publisher(s):
Elsevier BV; W.B. Saunders
Tags:
Medicine; connective tissue disease; smooth muscle atrophy; fibrosis; animal model; antibody; Gastroenterology
article description
Patients with systemic sclerosis (SSc) have impairments in gastrointestinal smooth muscle function. The disorder has been associated with circulating antibodies to cholinergic muscarinic the type-3 receptor (M(3)-R). We investigated whether it is possible to neutralize these antibodies with pooled human IgGs (pooledhIgG).