Effects of scleroderma antibodies and pooled human immunoglobulin on anal sphincter and colonic smooth muscle function.
- Citation data:
Gastroenterology, ISSN: 1528-0012, Vol: 143, Issue: 5, Page: 1308-1318
- Publication Year:
- Repository URL:
- https://works.bepress.com/vaibhav_mehendiratta/7; https://jdc.jefferson.edu/gastro_hepfp/14
- Medicine; connective tissue disease; smooth muscle atrophy; fibrosis; animal model; antibody; Gastroenterology
Patients with systemic sclerosis (SSc) have impairments in gastrointestinal smooth muscle function. The disorder has been associated with circulating antibodies to cholinergic muscarinic the type-3 receptor (M(3)-R). We investigated whether it is possible to neutralize these antibodies with pooled human IgGs (pooledhIgG).