In vitro migration of cytotoxic T lymphocyte derived from a colon carcinoma patient is dependent on CCL2 and CCR2.

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Journal of translational medicine, ISSN: 1479-5876, Vol: 9, Issue: 1, Page: 33

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Berencsi, Klara; Rani, Pyapalli; Zhang, Tianqian; Gross, Laura; Mastrangelo, Michael; Meropol, Neal J; Herlyn, Dorothee; Somasundaram, Rajasekharan
Springer Nature
Biochemistry, Genetics and Molecular Biology; Thomas Jefferson University; Department of Medical Oncology; Animals; Apoptosis; Cell Line; Tumor; Cell Movement; Chemokine CCL2; Colonic Neoplasms; Humans; Lymphocytes; Tumor-Infiltrating; Mice; Phenotype; Receptors; CCR2; T-Lymphocytes; Cytotoxic; Time Factors; Tumor Markers; Biological; Medical Immunology; Oncology
article description
Infiltration of colorectal carcinomas (CRC) with T-cells has been associated with good prognosis. There are some indications that chemokines could be involved in T-cell infiltration of tumors. Selective modulation of chemokine activity at the tumor site could attract immune cells resulting in tumor growth inhibition. In mouse tumor model systems, gene therapy with chemokines or administration of antibody (Ab)-chemokine fusion proteins have provided potent immune mediated tumor rejection which was mediated by infiltrating T cells at the tumor site. To develop such immunotherapeutic strategies for cancer patients, one must identify chemokines and their receptors involved in T-cell migration toward tumor cells.