Basal Flt1 tyrosine kinase activity is a positive regulator of endothelial survival and vascularization during zebrafish embryogenesis.

Citation data:

Biochimica et biophysica acta, ISSN: 0006-3002, Vol: 1850, Issue: 2, Page: 373-84

Publication Year:
2015
Usage 35
Abstract Views 34
Link-outs 1
Citations 8
Citation Indexes 8
Repository URL:
http://repository.vtc.edu.hk/thei-fac-sci-tech-sp/49
PMID:
25450186
DOI:
10.1016/j.bbagen.2014.10.023
Author(s):
Li, Shang; Zhou, Xue Lin; Dang, Yuan Ye; Kwan, Yiu Wa; Chan, Shun Wan; Leung, George Pak Heng; Lee, Simon Ming-Yuen; Hoi, Maggie Pui Man
Publisher(s):
Elsevier BV; VTC Institutional Repository
Tags:
Biochemistry, Genetics and Molecular Biology; Flt1; VEGF receptor inhibitor; Calycosin; Zebrafish; Endothelial cell; Molecular docking; Medical Biochemistry
article description
The role of Kdr (VEGFR-2/Flk-1) in vascular formation has been well described, but the role of Flt1 (VEGFR-1) is not well studied and is generally considered as a decoy receptor for trapping VEGF.