Galvanic coupling conducting polymers to biodegradable Mg initiates autonomously powered drug release

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Journal of Materials Chemistry, ISSN: 0959-9428, Vol: 18, Issue: 30, Page: 3608-3613

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Moulton, Simon Edward; Imisides, Mark David; Shepherd, Roderick Leonard; Wallace, Gordon George
Royal Society of Chemistry (RSC); The Royal Society of Chemistry
Chemistry; Materials Science; Galvanic; coupling; conducting; polymers; biodegradable; initiates; autonomously; powered; drug; release; Life Sciences; Physical Sciences and Mathematics; Social and Behavioral Sciences
article description
Electrical stimulation to affect localised and controlled release of therapeutic drugs is becoming an attractive option in the treatment of acute diseases or chronic illnesses. Currently the materials developed for this technique rely on power sources to operate, making their progression from the laboratory to the biomedical marketplace problematic. To help alleviate this issue, we have demonstrated autonomously powered controlled release of a drug by exploiting the galvanic couple between biodegradable Mg alloy and a conducting organic polymer. We also demonstrate the ability to control the rate of drug release by utilizing a range of biodegradable polymer coatings on the Mg alloy. Combination of the biodegradable Mg and conducting polymer provides a biocompatible platform for the autonomously controlled release of a drug at therapeutic levels. © 2008 The Royal Society of Chemistry.