Synthesis of (+)-(1 R ,2 S ,9 S ,9 aR )-octahydro-1 H -pyrrolo[1,2- a ]azepine-1,2,9-triol: a potential glycosidase inhibitor
- Citation data:
Tetrahedron, ISSN: 0040-4020, Vol: 60, Issue: 19, Page: 4173-4176
- Publication Year:
- Biochemistry, Genetics and Molecular Biology; Chemistry; Pharmacology, Toxicology and Pharmaceutics; CMMB; Life Sciences; Physical Sciences and Mathematics; Social and Behavioral Sciences
The title compound was prepared as a potential glycosidase inhibitor. Key steps in the synthesis are vinyl epoxide aminolysis, ring-closing metathesis, cis -dihydroxylation and then ring closure.