Synthesis of (+)-(1 R ,2 S ,9 S ,9 aR )-octahydro-1 H -pyrrolo[1,2- a ]azepine-1,2,9-triol: a potential glycosidase inhibitor

Citation data:

Tetrahedron, ISSN: 0040-4020, Vol: 60, Issue: 19, Page: 4173-4176

Publication Year:
2004
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Citations 38
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Repository URL:
http://ro.uow.edu.au/scipapers/5311
DOI:
10.1016/j.tet.2004.03.050
Author(s):
Lindsay, Karl B.; Pyne, Stephen G
Publisher(s):
Elsevier BV
Tags:
Biochemistry, Genetics and Molecular Biology; Chemistry; Pharmacology, Toxicology and Pharmaceutics; CMMB; Life Sciences; Physical Sciences and Mathematics; Social and Behavioral Sciences
article description
The title compound was prepared as a potential glycosidase inhibitor. Key steps in the synthesis are vinyl epoxide aminolysis, ring-closing metathesis, cis -dihydroxylation and then ring closure.