Discovery of a non-peptidic inhibitor of west nile virus NS3 protease by high-throughput docking.

Citation data:

PLoS neglected tropical diseases, ISSN: 1935-2735, Vol: 3, Issue: 1, Page: e356

Publication Year:
2009
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Repository URL:
http://ro.uow.edu.au/scipapers/865
PMID:
19159012
DOI:
10.1371/journal.pntd.0000356
PMCID:
PMC2613028; 2613028
Author(s):
Dariusz Ekonomiuk; Xun-Cheng Su; Kiyoshi Ozawa; Christophe Bodenreider; Siew Pheng Lim; Zheng Yin; Thomas H. Keller; David Beer; Viral Patel; Gottfried Otting; Amedeo Caflisch; Danzhi Huang; Diane Joseph-McCarthy Show More Hide
Publisher(s):
Public Library of Science (PLoS); Figshare
Tags:
Medicine; ns3; protease; high; discovery; non; peptidic; throughput; inhibitor; docking; west; nile; virus; Biochemistry; Biophysics; non-peptidic; high-throughput; Life Sciences; Physical Sciences and Mathematics; Social and Behavioral Sciences
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article description
The non-structural 3 protease (NS3pro) is an essential flaviviral enzyme and therefore one of the most promising targets for drug development against West Nile virus (WNV) and dengue infections.