Discovery of a non-peptidic inhibitor of west nile virus NS3 protease by high-throughput docking.
- Citation data:
PLoS neglected tropical diseases, ISSN: 1935-2735, Vol: 3, Issue: 1, Page: e356
- Publication Year:
- Repository URL:
- PMC2613028; 2613028
- Medicine; ns3; protease; high; discovery; non; peptidic; throughput; inhibitor; docking; west; nile; virus; Biochemistry; Biophysics; non-peptidic; high-throughput; Life Sciences; Physical Sciences and Mathematics; Social and Behavioral Sciences
The non-structural 3 protease (NS3pro) is an essential flaviviral enzyme and therefore one of the most promising targets for drug development against West Nile virus (WNV) and dengue infections.