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Rethinking metabotropic glutamate receptor 5 pathological findings in psychiatric disorders: implications for the future of novel therapeutics.
- Citation data:
BMC psychiatry, ISSN: 1471-244X, Vol: 14, Issue: 1, Page: 23
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- Repository URL:
- PMC3907147; 3907147
- Medicine; Metabotropic glutamate receptor; mGlu; mGluR5; GRM; Schizophrenia; Depression; Post-mortem human brain; Novel antipsychotic; Novel antidepressant; Glutamate; CMMB; Medicine and Health Sciences; Social and Behavioral Sciences
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Pharmacological modulation of metabotropic glutamate receptor 5 (mGluR5) is of marked interest as a novel therapeutic mechanism to treat schizophrenia and major depression. However, the status of mGluR5 in the pathophysiology of these disorders remains unknown.