CD30+ reversible lymphoid dyscrasia (pseudolymphoma) following HIDA scintigraphy and the [Ring1]-[Ring2]-[C=O] generalized structure hypothesis.

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Journal of the American Academy of Dermatology, ISSN: 1097-6787, Vol: 68, Issue: 3, Page: e99-101

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Rader, Ryan K.; Stoecker, William V.; Hinton, Kristen A.; Malone, Janine C.; Schuman, Thomas P.
Elsevier BV; Elsevier
Medicine; Chemistry
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To the Editor: Eighteen days after hepatobiliary iminodiacetic acid (HIDA) scintigraphy, an 81-year-old woman presented with pruritic, painful, discrete, tender papules in a generalized distribution (Fig 1). She noted onset of the eruption shortly after the HIDA scan. Biopsy specimen of 2 papules from the right thigh showed an infiltration of mitotically active lymphocytes (Fig 1, top inset) confined to the upper dermis. The lymphocytes were predominantly CD3+ T cells; occasional scattered CD20+ B cells were present. CD4 and CD8 were present in an approximately 2:1 ratio, and both cell types were noted within the epidermis. Small aggregates of large CD3+/CD30+ lymphocytes were present, comprising less than 25% of the lymphoid population (Fig 1, bottom inset). The histopathology and immunostaining supported a diagnosis of CD30+ plasma cell dyscrasia (pseudolymphoma).