Enantiomeric Composition of Nicotine in Smokeless Tobacco, Medicinal Products, and Commercial Reagents

Citation data:

Chirality

Publication Year:
1998
Usage 7
Abstract Views 7
Repository URL:
http://scholarsmine.mst.edu/chem_facwork/303
Author(s):
Armstrong, Daniel W.; Wang, Xiande; Ercal, Nuran
Publisher(s):
John Wiley & Sons
Tags:
Chemistry
article description
The enantiomeric composition of nicotine in 18 smokeless tobaccos, 3 strains of tobacco leaf, 8 pharmaceutical products, and 4 commercial reagents was determined. The relative amount of the minor enantiomeric component, (R)-(+)-nicotine, ranged from 0.1% to 1.2% of the total nicotine in all samples. In some cases it appears that (R)-(+)-nicotine may be considered one of the five most common alkaloids in tobacco products. The highest level of (R)-(+)-nicotine was found in a commercial transdermal patch. The extraction and purification processes used in obtaining commercial (S)-(-)-nicotine supplies from tobacco do not appear to decrease the amount of (R)-(+)-nicotine present.