Validation study of urinary metabolites as potential biomarkers for prostate cancer detection.

Citation data:

Bioanalysis, ISSN: 1757-6199, Vol: 4, Issue: 10, Page: 1175-83

Publication Year:
2012
Usage 26
Abstract Views 19
Link-outs 7
Captures 1
Readers 1
Citations 7
Citation Indexes 7
Repository URL:
http://scholarsmine.mst.edu/chem_facwork/637
PMID:
22651561
DOI:
10.4155/bio.12.92
Author(s):
Gamagedara, Sanjeewa; Kaczmarek, Anthony T; Jiang, Yongqing; Cheng, Xiaoliang; Rupasinghe, Maduka; Ma, Yinfa
Publisher(s):
Future Science, LTD; Future Science
Tags:
Chemistry; Pharmacology, Toxicology and Pharmaceutics; Biochemistry, Genetics and Molecular Biology; Health Professions; 80 And Over; Adolescent; Adult; Aged; Analytic Method; Biological; Bladder Cancer; Cancer Diagnosis; Cancer Staging; Case-Control Studies; Chromatography; Controlled Study; Creatinine; Creatinine Urine Level; Diagnosis; Differential; Differential Diagnosis; Female; Gleason Score; Glycerol 3 Phosphate Dehydrogenase; Glycerophosphates; High Performance Liquid Chromatography; High Pressure Liquid; Human; Kynurenine; Major Clinical Study; Male; Metabolomics; Middle Aged; Multivariate Analysis; Neoplasm Grading; Proline; Prostate Cancer; Prostate Specific Antigen; Prostatic Neoplasms; Statistical Analysis; Tandem Mass Spectrometry; Tumor Markers; Uracil; Urinary Bladder Neoplasms; Validation Process; 80 And Over; Adolescent; Adult; Aged; Analytic Method; Biological; Bladder Cancer; Cancer Diagnosis; Cancer Staging; Case-Control Studies; Chromatography; Controlled Study; Creatinine; Creatinine Urine Level; Diagnosis; Differential; Differential Diagnosis; Female; Gleason Score; Glycerol 3 Phosphate Dehydrogenase; Glycerophosphates; High Performance Liquid Chromatography; High Pressure Liquid; Human; Kynurenine; Major Clinical Study; Male; Metabolomics; Middle Aged; Multivariate Analysis; Neoplasm Grading; Proline; Prostate Cancer; Prostate Specific Antigen; Prostatic Neoplasms; Statistical Analysis; Tandem Mass Spectrometry; Tumor Markers; Uracil; Urinary Bladder Neoplasms; Validation Process
article description
Urinary metabolomic profiles have recently drawn a lot of attention owing to a debate regarding their possible role as potential clinical markers for prostate cancer. In this study, levels of proline, kynurenine, uracil and glycerol-3-phosphate in 126 patients with genitourinary malignancies were analyzed using a validated method and compared with no evidence of malignancy.