Blockade of MGMT expression by O6 benzyl guanine leads to inhibition of pancreatic cancer growth and induction of apoptosis.

Citation data:

Clinical cancer research : an official journal of the American Association for Cancer Research, ISSN: 1078-0432, Vol: 15, Issue: 19, Page: 6087-95

Publication Year:
2009
Usage 18
Abstract Views 18
Captures 3
Readers 3
Citations 25
Citation Indexes 25
Repository URL:
http://stars.library.ucf.edu/facultybib2000/1744; http://stars.library.ucf.edu/facultybib/11891
PMID:
19789303
DOI:
10.1158/1078-0432.ccr-09-0887
Author(s):
Konduri, Santhi D; Ticku, Jonathan; Bobustuc, George C; Sutphin, Robert M; Colon, Jimmie; Isley, Beth; Bhakat, Kishor K; Srivenugopal, Kalkunte S; Baker, Cheryl H
Publisher(s):
American Association for Cancer Research (AACR)
Tags:
Medicine; Biochemistry, Genetics and Molecular Biology; HUMAN O-6-METHYLGUANINE-DNA METHYLTRANSFERASE; CELL-CYCLE; ALKYLATING-AGENTS; DRUG-RESISTANCE; GENE-EXPRESSION; FACTOR RECEPTOR; POTENTIAL ROLE; P53; PROTEIN; THERAPY; Oncology
article description
We sought to determine whether administration of a MGMT blocker, O(6)-benzyl guanine (O(6)BG), at an optimal biological dose alone or in combination with gemcitabine inhibits human pancreatic cancer cell growth.