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Role of Endosialin/CD248 and Cytoglobin In liver fibrosis

Al-Azhar International Medical Journal, Vol: 4, Issue: 8
2023
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Background - Chronic liver diseases are a major global health burden. CYGB, Human IV globin is abundantly expressed in Hepatic Stellate Cell(HSCs) between hepatocytes. CYGB can bind oxygen and nitric oxide and is said to protect HSCs from reactive oxygen species(ROS).Aim - to estimate role of CD248 and Cygb in process of liver fibrosis.Patients and Methods - This study was conducted on forty-four Egyptian patients with hepatic stenosis detected by ultrasound, and forty healthy volunteers as control group.Results - Our results showed statistical significant (p-value < 0.001) increased CD248 in patients group (189.03 ± 66.6) when compared with control group (138.7 ± 36.5), decreased Cygb in patients group (1.62 ± 0.35) when compared with control group (1.93 ± 0.26)Conclusion - Our study identified Cygb and CD248 as a novel therapeutic-targets in liver-fibrosis.

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