Management algorithm for subclinical hypoxemia in coronavirus disease-2019 patients: Intercepting the 'Silent Killer'

In the early stages of COVID-19 clinical illness, the ability to oxygenate is impaired. However, the patient does not necessarily display the conventionally expected signs or symptoms of respiratory failure, including shortness of breath. Given the above, HCP's must remain vigilant and proactively look for 'red flags' described herein, such as the appearance of =3%-5% drop in SpO2 after approximately 60 s of mild activity/ambulation, SpO2/FiO2 ratio <300, SpO2 <93% on room air, and the presence of hypoxemia without tachypnea [Figure 1].[4,11,12] In summary, this expert group views AH as the proverbial "canary in the coalmine" and the first harbinger of future respiratory deterioration in COVID-19 patients.