7-OH-DPAT, unlike quinpirole, does not prime a yawning response in rats
Pharmacology Biochemistry and Behavior, ISSN: 0091-3057, Vol: 67, Issue: 1, Page: 11-15
2000
- 17Citations
- 1Usage
- 5Captures
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Metrics Details
- Citations17
- Citation Indexes17
- 17
- CrossRef11
- Usage1
- Abstract Views1
- Captures5
- Readers5
Article Description
Repeated treatment in ontogeny with the dopamine (DA) D 2 /D 3 receptor agonist quinpirole is associated with enhanced quinpirole-induced yawning and other behaviors such as vacuous chewing, vertical jumping, and antinociception. To determine if the reputedly DA D 3 agonist (±)-2-(dipropylamino)-7-hydroxy-1,2,3,4-tetrahydronaphthalene (7-OH-DPAT) would prime for yawning in a manner analogous to that for quinpirole, rats were treated for the first 11 days after birth with an equimolar dose of either quinpirole or 7-OH-DPAT (195.4 nmol/kg/day) and tested for agonist-induced yawning in adulthood. While enhanced quinpirole-induced and 7-OH-DPAT-induced yawning was observed in quinpirole-primed rats, acute treatments with quinpirole and 7-OH-DPAT did not produce an enhanced yawing response in 7-OH-DPAT-“primed” rats. Our findings indicate that 7-OH-DPAT, unlike quinpirole, does not prime for quinpirole- or 7-OH-DPAT-induced yawning in rats.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0091305700002963; http://dx.doi.org/10.1016/s0091-3057(00)00296-3; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0033666357&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/11113478; https://linkinghub.elsevier.com/retrieve/pii/S0091305700002963; http://linkinghub.elsevier.com/retrieve/pii/S0091305700002963; http://api.elsevier.com/content/article/PII:S0091305700002963?httpAccept=text/xml; http://api.elsevier.com/content/article/PII:S0091305700002963?httpAccept=text/plain; https://dc.etsu.edu/etsu-works/14496; https://dc.etsu.edu/cgi/viewcontent.cgi?article=15762&context=etsu-works; http://dx.doi.org/10.1016/s0091-3057%2800%2900296-3; https://dx.doi.org/10.1016/s0091-3057%2800%2900296-3
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