Molecular and physiological factors of neuroprotection in hypoxia-tolerant models: Pharmacological clues for the treatment of stroke
Journal of Experimental Neuroscience, ISSN: 1179-0695, Vol: 9, Issue: 1, Page: 1-5
2015
- 7Citations
- 127Usage
- 23Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations7
- Citation Indexes7
- CrossRef2
- Usage127
- Abstract Views108
- Downloads19
- Captures23
- Readers23
- 23
Article Description
The naked mole-rat possesses several unique physiological and molecular features that underlie their remarkably and exceptional resistance to tissue hypoxia. Elevated pattern of Epo, an erythropoietin (Epo) factor; c-fos; vascular endothelial growth factor (VEGF); and hypoxia-inducible factors (HIF-1α) contribute to the adaptive strategy to cope with hypoxic stress. Moreover, the naked mole-rat has a lower metabolic rate than any other eutherian mammal of comparable size that has been studied. The ability to actively reduce metabolic rate represents a strategy widely used in the face of decreased tissue oxygen availability. Understanding the different molecular and physiological factors that induce metabolic suppression could guide the development of pharmacological agents for the clinical management of stroke patient.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84929858848&origin=inward; http://dx.doi.org/10.4137/jen.s22512; http://www.ncbi.nlm.nih.gov/pubmed/25780340; https://journals.sagepub.com/doi/10.4137/JEN.S22512; http://journals.sagepub.com/doi/10.4137/JEN.S22512; https://dc.etsu.edu/etsu-works/15555; https://dc.etsu.edu/cgi/viewcontent.cgi?article=16821&context=etsu-works; https://www.airitilibrary.com/Article/Detail/P20160629006-201512-201606290033-201606290033-1-5; http://www.la-press.com/molecular-and-physiological-factors-of-neuroprotection-in-hypoxia-tole-article-a4691; http://insights.sagepub.com/molecular-and-physiological-factors-of-neuroprotection-in-hypoxia-tole-article-a4691; http://insights.sagepub.com/redirect_file.php?fileId=6289&filename=4691-JEN-Molecular-and-Physiological-Factors-of-Neuroprotection-in-Hypoxia-tole.pdf&fileType=pdf
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