Saudiarabicains A-E, bioactive 19-acetoxyingol diterpenoids from Euphorbia saudiarabica
Tetrahedron Letters, ISSN: 0040-4039, Vol: 61, Issue: 32, Page: 152203
2020
- 5Citations
- 12Usage
- 3Captures
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Metrics Details
- Citations5
- Citation Indexes5
- Usage12
- Abstract Views12
- Captures3
- Readers3
Article Description
Five new 19-acetoxyingols were isolated from the aerial parts of Euphorbia saudiarabica. They included two uncommon pentacyclic acetoxyingols ( 1, 2 ) and two 2,3-diepimers ( 3, 4 ), representing the first report of 19-acetoxyingols epimers. Their structures were determined by analysis of extensive 1D and 2D NMR spectroscopic data. The absolute configurations were established by experimental and calculated CD analysis. Compounds 3 – 5 showed α-glucosidase inhibitory effects superior to the positive control, acarbose (IC 50 9.1, 8.0, 1.8 vs 147 µM, respectively). Compounds 1, 2, 4, and 5 showed inhibitory effects on human P-glycoprotein comparable to the positive control, valspodar (IC 50 0.1–1.4 vs 0.2 µM, respectively).
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0040403920306687; http://dx.doi.org/10.1016/j.tetlet.2020.152203; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85087961298&origin=inward; https://linkinghub.elsevier.com/retrieve/pii/S0040403920306687; https://api.elsevier.com/content/article/PII:S0040403920306687?httpAccept=text/xml; https://api.elsevier.com/content/article/PII:S0040403920306687?httpAccept=text/plain; https://dul.usage.elsevier.com/doi/; https://digitalcommons.uri.edu/bps_facpubs/344; https://digitalcommons.uri.edu/cgi/viewcontent.cgi?article=1346&context=bps_facpubs; https://dx.doi.org/10.1016/j.tetlet.2020.152203
Elsevier BV
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