Partnership for International Research and Education in Microfluidic Technology with Applications in Point of Care Diagnostic

This poster summarizes the research highlights of a project conducted as part of an National Science Foundation (NSF) partnership for research and education. The objective of this multidisciplinary, international project was to conduct research on microfluidic technology and applications. The project team is comprised of participants from the University of Rhode Island and the Technical University of Braunschweig in Germany. The research focuses on the following four tasks: Task 1 – Discovery of disease biomarkers; Task 2 –Streaming based microfluidic platform for pumping, mixing, separation and detection; Task 3 – Development of rapid, quantitative and sensitive microfluidic fluorescence immunosensors for point-of-care diagnostics; and Task 4 – Microfluidic ocean based applications. The following elements are examined in Task 3: Enzyme-linked Immunosorbent Assay (ELISA) by manipulation of magnetic beads in microfluidic channel network; development of charged coupled device (CCD) contact imaging system for lab-on-a-chip biosensors for detection of disease biomarkers; a portable and hand-held lab-on-a-chip system for detection of disease biomarkers; on-chip valveless sequential sample loading, mixing, and micro-pneumatic valves; and numerical simulation of microfluidics using dissipative particle dynamics.