Histological Evidence Of The Effect Of Oil Palm Phenolics In Atherogenic Diet Induced Rat Model Of Alzheimer’s Disease
2016
- 724Usage
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Usage724
- Downloads660
- Abstract Views64
Thesis / Dissertation Description
BACKGROUND: Alzheimer’s disease (AD) is a neurodegenerative disease with the clinical presentation of memory loss and cognitive impairment. Alzheimer's disease pathology is the accumulation of beta amyloid plaques and neurofibrillary tangles.METHOD: In this study atherogenic diet was used to induce AD in aged Brown Norway rats. The rats were assigned to the following four groups fed isocaloric diets; control group (C ),high cholesterol diet (H), high cholesterol + oil palm phenolics group (HP), high cholesterol + curcumin group (HC). The impact of oil palm phenolics (OPP) on neuronal health and its effect on amyloid deposition was evaluated using histology and ELISA. The cognitive ability of the rats were tested using Morris water maze.RESULTS: Our model was successful in facilitating the formation of extracellular beta amyloid plaques and causing neuronal loss. Histological findings revealed better neuronal health in the group of rats offered OPP in their diets compared to the high cholesterol only fed rats. The Morris water maze test showed better learning and cognition in rats fed the OPP diet.CONCLUSION: OPP provided neuronal protection and decreased the deposition of beta amyloid plaques in the hippocampus of the rats.
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