Cobalt(II) Diphenylazodioxide Complexes Induce Apoptosis in SK-HEP-1 Cells
ACS Omega, ISSN: 2470-1343, Vol: 4, Issue: 11, Page: 14503-14510
2019
- 22Citations
- 151Usage
- 22Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations22
- Citation Indexes22
- 22
- CrossRef12
- Usage151
- Downloads129
- Abstract Views22
- Captures22
- Readers22
- 22
Article Description
The cobalt(II) complex salts [Co(bpy)(az)](PF) and [Co(az)](PF), each bearing the unusual cis-N,N-diphenylazodioxide ligand, were both screened as possible anticancer agents against SK-HEP-1 liver cancer cells. Both compounds were found to induce substantial apoptosis as an increasing function of concentration and time. Measurement of apoptosis-related proteins indicated that both the extrinsic and intrinsic pathways of apoptosis were activated. The apoptotic activity induced by these salts is not displayed either by simple cobalt(II) salts or complexes or by the free nitrosobenzene ligand. Additionally, these compounds did not induce apoptosis, as assessed by poly(adenosine diphosphate-ribose) polymerase cleavage, in several other cell lines.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85072578358&origin=inward; http://dx.doi.org/10.1021/acsomega.9b01684; http://www.ncbi.nlm.nih.gov/pubmed/31528804; https://pubs.acs.org/doi/10.1021/acsomega.9b01684; https://engagedscholarship.csuohio.edu/scichem_facpub/516; https://engagedscholarship.csuohio.edu/cgi/viewcontent.cgi?article=1521&context=scichem_facpub
American Chemical Society (ACS)
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