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Cabotegravir is not associated with weight gain in human immunodeficiency virus-uninfected individuals in HPTN 077

Clinical Infectious Diseases, ISSN: 1537-6591, Vol: 70, Issue: 2, Page: 319-322
2020
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HIV drug cabotegravir not associated with weight gain

The novel integrase inhibitor cabotegravir — which is currently in development for both HIV prevention and treatment — was not associated with excess weight gain in HIV-uninfected patients compared with placebo, according to a recent study. “ART that contains an integrase inhibitor has been associated with weight gain and increased waist circumference, with changes of greater magnitude seen among

Article Description

Studies in human immunodeficiency virus (HIV)-infected individuals suggest excess weight gain with integrase inhibitor- based antiretroviral therapy. The HIV Prevention Trials Network Study 077 evaluated changes in weight and fasting metabolic parameters in HIV-uninfected individuals randomized to cabotegravir or a placebo. No differences between arms were found for change in weight or fasting metabolic parameters overall or for subgroups.

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