Reduced expression of mir15a in the blood of patients with oral squamous cell carcinoma is associated with tumor staging
Experimental and Therapeutic Medicine, ISSN: 1792-0981, Vol: 1, Issue: 1, Page: 217-221
2010
- 17Citations
- 78Usage
- 19Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations17
- Citation Indexes17
- 17
- CrossRef5
- Usage78
- Downloads78
- Captures19
- Readers19
- 19
Article Description
MicroRNAs (miRNAs) mir15a and let7a are important regulators of bcl-2, ras and c-myc proteins. considering that these miRNAs are commonly altered in many human cancers and that these proteins are reported to be altered in oral squamous cell carcinoma (OSCC), we investigated them in a set of OSCC cases. The mirnas as well as the proteins were evaluated in the tumor and blood of 20 patients by real-time quantitative PCR and Immuno histochemistry, respectively. The expression of mir15a and bcl-2 proteins in the tumors was not associated with each other or with tumor staging. On the other hand, we found reduced expression of this mirna in the blood of patients with an advanced stage of OSCC and with lymph node metastasis. The expression of let7a in the tumor and blood was not associated with tumor size, lymph node metastasis, tumor staging and immunoexpression of ras and c-myc proteins. In conclusion, the present study shows that reduced expression of mir15a is associated with OSCC staging.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=77955796432&origin=inward; http://dx.doi.org/10.3892/etm_00000035; http://www.ncbi.nlm.nih.gov/pubmed/23136618; https://www.spandidos-publications.com/10.3892/etm_00000035; http://www.spandidos-publications.com/etm/1/1/217; http://dx.doi.org/10.3892/etm_0000035; https://ir.lib.uwo.ca/anatomypub/66; https://ir.lib.uwo.ca/cgi/viewcontent.cgi?article=1067&context=anatomypub; https://dx.doi.org/10.3892/etm_00000035; http://www.spandidos-publications.com/10.3892/etm_00000035/abstract; http://www.spandidos-publications.com/10.3892/etm_00000035/download; https://www.spandidos-publications.com/etm/1/1/217
Spandidos Publications
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