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Synthesis of Cycloparaphenyleneacetylene via Alkyne Metathesis: C Complexation and Copper-Free Triple Click Reaction

Journal of the American Chemical Society, ISSN: 1520-5126, Vol: 138, Issue: 42, Page: 13814-13817
2016
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Article Description

Alkyne metathesis provided an efficient macrocyclization route to a cycloparaphenyleneacetylene derivative in high yield. The cavity size was suitably matched for C which was tightly bound in an induced-fit fashion. The strained alkynes enabled a copper-free, 3-fold azide-alkyne cycloaddition at 50 °C.

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