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Determination of the Solution Conformation of 3'-Azido-3'-deoxythymidine-5'-monophosphate (AZTMP): An Advanced Chemistry and Biochemistry Project Using NMR and Molecular-Modeling Studies

Vol: 73, Issue: 2
1996
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The conformation of 3'-Azido-3'-deoxythymidine-5'-monophosphate (AZTMP) in an aqueous solution buffered at pH 7.2 was determined using a combination of NMR (1H and 31P) and molecular modelling techniques. Under the conditions studied, AZTMP was found to adopt a C1'-exo, primarily beta(t) and gamma(+) conformation with torsional angle -139.9 degrees. The conformation of 3'-Azido-3'-deoxythymidine-5'-monophosphate (AZTMP) in an aqueous solution buffered at pH 7.2 was determined using a combination of NMR (1H and 31P) and molecular modelling techniques. Under the conditions studied, AZTMP was found to adopt a C1'-exo, primarily beta(t) and gamma(+) conformation with torsional angle -139.9 degrees.

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