Sequence specific recognition of DNA by tailor-made hairpin conjugates of achiral seco -cyclopropaneindoline-2-benzofurancarboxamide and pyrrole–imidazole polyamides
Bioorganic & Medicinal Chemistry Letters, ISSN: 0960-894X, Vol: 15, Issue: 12, Page: 3151-3156
2005
- 3Citations
- 4Captures
Metric Options: Counts1 Year3 YearSelecting the 1-year or 3-year option will change the metrics count to percentiles, illustrating how an article or review compares to other articles or reviews within the selected time period in the same journal. Selecting the 1-year option compares the metrics against other articles/reviews that were also published in the same calendar year. Selecting the 3-year option compares the metrics against other articles/reviews that were also published in the same calendar year plus the two years prior.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Article Description
Hairpin conjugates of achiral seco -cyclopropaneindoline-2-benzofurancarboxamide (achiral seco -CI-Bf) and three diamides (ImPy 1, PyIm 2, and PyPy 3, where Py is pyrrole, and Im is imidazole), linked by a γ-aminobutyrate group, were synthesized. The sequence-specific covalent alkylation of the achiral CI moiety with adenine-N3 in the minor groove was ascertained by thermally induced DNA cleavage experiments. The results provide evidence that hairpin conjugates of achiral seco -CI-Bf-γ-polyamides could be tailored to target specific DNA sequences according to a set of general rules: the achiral CI moiety selectively reacts with adenine-N3, a stacked pair of imidazole/benzofuran prefers a G/C base pair, and a pyrrole/benzofuran prefers an A/T or T/A base pair. Models for the binding of hairpin conjugates 1 – 3 with sequences 5′-TC A (888)G-3′, 5′-CA A (857)C-3′, and 5′-TT A (843)C-3′ are proposed.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0960894X0500449X; http://dx.doi.org/10.1016/j.bmcl.2005.04.006; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=19944384248&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/15876536; https://linkinghub.elsevier.com/retrieve/pii/S0960894X0500449X; https://scholarexchange.furman.edu/chm-citations/262; https://scholar.google.com/scholar?q=10.1016/j.bmcl.2005.04.006; https://dx.doi.org/10.1016/j.bmcl.2005.04.006; http://www.sciencedirect.com/science/article/pii/S0960894X0500449X?via%3Dihub; http://linkinghub.elsevier.com/retrieve/pii/S0960894X0500449X
Elsevier BV
Provide Feedback
Have ideas for a new metric? Would you like to see something else here?Let us know