Systems Biology Modeling of Cancer Nonlinear Dynamics
2023
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
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Article Description
Not unlike the climate or what holds the galaxies and planetary motions together, cancer biology has an intrinsic nonlinear dynamic. In this overview we will outline how to connect temporal measurements of a nonlinear dynamical and unstable complex system, such as cancer, with well-established engineering methods, old and new, that are applied in linear dynamical systems.This proof-of-concept is therapeutically relevant in the development of new means to treat or control human cancer by either adding an appropriate external "damping" or a "forcing" term, or by a "control" actuator such that its nonlinear dynamic is steered to a spiral stably into zero forever as a sink attractor.Keywords: Actuator; Cancer; Dynamic mode decomposition; Frobenius norm; Gene regulation; Genetic programming and analytical differentiation; Gillespie stochastic algorithm; Least absolute shrinkage and selection operator; Linear and nonlinear dynamic; Pareto front; Sparsity technique.
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